Laurent Servais Selected Research

Zolgensma

1/2022	Onasemnogene abeparvovec for presymptomatic infants with two copies of SMN2 at risk for spinal muscular atrophy type 1: the Phase III SPR1NT trial.
1/2022	Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial.
1/2022	Onasemnogene abeparvovec for the treatment of spinal muscular atrophy.
10/2021	Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy type 1 (STR1VE-EU): an open-label, single-arm, multicentre, phase 3 trial.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Laurent Servais Research Topics

Disease

24	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2022 - 01/2014
18	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 07/2022 - 07/2014
6	Muscular Dystrophies (Muscular Dystrophy) 01/2018 - 07/2014
5	Congenital Structural Myopathies (Centronuclear Myopathy) 01/2022 - 11/2017
5	Neuromuscular Diseases (Neuromuscular Disease) 11/2021 - 11/2017
4	Disease Progression 07/2020 - 05/2015
3	Fever (Fevers) 01/2022 - 01/2014
3	Muscular Diseases (Myopathy) 01/2022 - 05/2014
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 08/2011
2	Angelman Syndrome (Syndrome, Angelman) 07/2021 - 12/2004
2	Ataxia (Dyssynergia) 01/2017 - 09/2005
2	Sarcoglycanopathies 09/2015 - 01/2013
2	Cardiomyopathies (Cardiomyopathy) 11/2014 - 11/2014
2	Cerebellar Diseases (Cerebellar Syndrome) 05/2009 - 02/2006
1	Arthralgia (Joint Pain) 01/2022
1	Pneumonia (Pneumonitis) 01/2022
1	Urinary Tract Infections (Urinary Tract Infection) 01/2022
1	Aphthous Stomatitis (Aphthous Ulcer) 01/2022
1	Respiratory Insufficiency (Respiratory Failure) 01/2022
1	Muscle Weakness 01/2022
1	Exanthema (Rash) 01/2022
1	Body Weight (Weight, Body) 11/2021
1	Infections 10/2021
1	Central Nervous System Diseases (CNS Diseases) 10/2021
1	Respiratory Tract Infections (Respiratory Tract Infection) 10/2021
1	Neurodevelopmental Disorders 07/2021
1	Cough 01/2021
1	Rare Diseases (Rare Disease) 01/2021
1	Noonan Syndrome (Female Pseudo-Turner Syndrome) 01/2020
1	Neoplasms (Cancer) 01/2020
1	Inborn Genetic Diseases (Disease, Hereditary) 03/2018
1	Hearing Loss (Hearing Impairment) 01/2018
1	Wasting Syndrome (Wasting Disease) 01/2017
1	Myotonic Dystrophy (Dystrophia Myotonica) 01/2017
1	Glut1 Deficiency Syndrome 05/2016
1	Brain Diseases (Brain Disorder) 01/2016
1	Rupture 01/2016
1	Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia) 01/2016
1	Congenital myasthenic syndrome with episodic apnea 01/2016
1	Infantile onset spinocerebellar ataxia 01/2016
1	Cognitive Dysfunction 01/2016
1	Spinal Muscular Atrophies of Childhood (Werdnig Hoffman Disease) 01/2015
1	Heart Diseases (Heart Disease) 11/2014
1	Proteinuria 10/2014
1	Injection Site Reaction 10/2014
1	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 07/2014
1	type 2C Limb-girdle muscular dystrophy 01/2013

Drug/Important Bio-Agent (IBA)

11	Proteins (Proteins, Gene)FDA Link 07/2022 - 01/2014
11	Biomarkers (Surrogate Marker)IBA 01/2021 - 07/2014
9	DystrophinIBA 01/2021 - 01/2014
5	RisdiplamIBA 07/2022 - 01/2021
5	nusinersenIBA 01/2022 - 11/2017
4	Pharmaceutical PreparationsIBA 01/2022 - 01/2021
4	ZolgensmaIBA 01/2022 - 10/2021
4	MicroRNAs (MicroRNA)IBA 11/2020 - 01/2013
3	golodirsenIBA 01/2022 - 01/2020
2	Antisense OligonucleotidesIBA 01/2021 - 06/2020
2	MyostatinIBA 06/2020 - 11/2017
2	PRO051IBA 10/2014 - 01/2014
2	Ethanol (Ethyl Alcohol)IBA 05/2009 - 09/2005
1	Coenzyme A (CoA)IBA 01/2022
1	Alanine Transaminase (SGPT)IBA 10/2021
1	mesoglycanIBA 10/2021
1	UbiquitinIBA 07/2021
1	CholesterolIBA 01/2021
1	idebenoneIBA 01/2020
1	Growth Hormone (Somatotropin)IBA 01/2020
1	UridineIBA 03/2018
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2018
1	Ferritins (Ferritin)IBA 01/2018
1	IronIBA 01/2018
1	myotubularinIBA 11/2017
1	salicylhydroxamic acid (SHAM)IBA 11/2017
1	Amino Acid Transport System X-AG (Glutamate Transporter)IBA 01/2017
1	RNA (Ribonucleic Acid)IBA 01/2017
1	Therapeutic UsesIBA 05/2016
1	triheptanoinIBA 05/2016
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2016
1	Mitochondrial DNA (mtDNA)IBA 01/2016
1	Cholinergic Agents (Cholinergics)IBA 01/2016
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2016
1	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 01/2016
1	choline transporterIBA 01/2016
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 05/2015
1	Nonsense Codon (Nonsense Mutation)IBA 11/2014
1	ConnectinIBA 07/2014
1	ProteomeIBA 07/2014
1	AutoantibodiesIBA 05/2014
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2014

Therapy/Procedure

10	Therapeutics 10/2021 - 11/2009
2	Mechanical Ventilators (Ventilator) 01/2022 - 01/2021
1	Gastrostomy 01/2022
1	Artificial Respiration (Mechanical Ventilation) 01/2022
1	Investigational Therapies (Experimental Therapy) 05/2021
1	Wearable Electronic Devices 01/2021
1	Aftercare (After-Treatment) 01/2020
1	Hearing Aids (Hearing Aid) 01/2018
1	Ketogenic Diet 05/2016
1	Epidural Anesthesia 01/2016
1	Noninvasive Ventilation 01/2015